Naruto and Sakura do not give up on Sasuke: Naruto leaves Konoha to receive training from Jiraiya to prepare himself for the next time he encounters Sasuke, while Sakura becomes Tsunade's apprentice.
During the search, it is revealed that Orochimaru wishes to train Sasuke because of his powerful genetic heritage, the Sharingan.
In response, the leader of Konoha, the Fourth Hokage, seals the fox inside the body of his newborn son, Naruto Uzumaki, making Naruto a host of the beast; this costs Naruto's father his life, and the Third Hokage returns from retirement to become leader of Konoha again.
Naruto is often ridiculed by the Konoha villagers for being the host of the Nine-Tails.
when he showed up in Konoha to kidnap Naruto, he joins Orochimaru, hoping to gain from him the strength needed to kill Itachi.
The story takes a turn when Sasuke leaves the Konoha village and when Tsunade finds out, she sends a group of ninja, including Naruto, to retrieve Sasuke, but Naruto is unable to persuade or force him to come back.