Endometrial dating based on histomorphology
Every patient gave written informed consent voluntarily prior to participating in the study, which was approved by the Ethics Committee, Faculty of Medicine, Peking University Third Hospital.
All patients received a long protocol of pituitary down regulation with Alarelin (a kind of Gn RH agonist made by GL Biochem (Shanghai) Ltd, Shanghai, China) 150 mg by s.c.
Ovarian blood flow were obtained by color Doppler and the average of two ovaries were calculated.
Endometrial blood flow was detected by intra-endometrial or the adjacent sub-endometrial regions within 10 mm of the echogenic endometrial borders.
Of them 110 had primary infertility and 72 had secondary infertility.
Of the 182 patients, 100 had infertility caused by tubal disorders, 55 by male factors and 27 by ovulation failure.
Analysis was used together with computer algorithms to form the endometrial volume and indices of blood flow within the endometrium.Double thickness of the endometrium was measured (maximum distance between each myometrial/endometrial interface through the longitudinal axis of the uterus).Thereafter, color Doppler energy was superimposed on the 2-D Doppler studies were performed on selected areas.Intrauterine pregnancy with live fetus in Group C (62.2%) was much higher than that in Group A and B (0% and 17.1%, p less than or equal to 0.001).The implantation rate (33.2%) was much higher than that in Group A and B (0% and 19.90%, p less than or equal to 0.001).