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Triprolidine is used in Europe and has a shorter half-life than some antihistamines, but there it is not often used in the US for insomnia.(There are other types of antihistamines that affect H-2, H-3, and H-4 receptors.) People build up tolerance to them over time and when they stop taking them experience rebound insomnia.

The main use for niaprazine is its intense sedative effect (as opposed to its antihistamine effects).

There is also the possibility of drug resistance where the body adapts to the antihistimine and it doesn’t work as well.

It is usually not appropriate for use just as a sleep aid.

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